Testosterone Replacement Therapy (TRT)
Testosterone replacement therapy (TRT) treats clinically diagnosed hypogonadism — low testosterone confirmed by blood tests plus symptoms. Clinical practice guidelines from the Endocrine Society and the American Urological Association (AUA) require two separate morning testosterone measurements before starting treatment, and ongoing monitoring of blood counts and prostate markers while on it.
The directory lists 394 clinic profiles tagged for Testosterone Replacement Therapy (TRT). Listing tags reflect recorded text and do not confirm a clinic's current services. Eligible clinic price records are shown separately in the price index; website-published and clinic-confirmed sources are labeled separately. Confirm current prices and terms directly with the clinic. Average public Google rating across 59 rated clinics: 4.8★ from 4,882 reviews.
Treatment guide quick facts
| Topic | Guide summary |
|---|---|
| Price information | See eligible clinic-published records in the price index; confirm current prices and included services directly with a clinic |
| Diagnosis requires | Symptoms plus two morning total testosterone tests (Endocrine Society / AUA guidelines commonly use <300 ng/dL) |
| Baseline labs | Total testosterone ×2, LH/FSH, CBC (hematocrit), PSA, estradiol, metabolic panel |
| Time to effect | Libido/energy: 3–6 weeks; body composition: 3–6 months |
| Monitoring | Testosterone, hematocrit, and PSA rechecked at roughly 3, 6, and 12 months, then annually |
How many clinics offer Testosterone Replacement Therapy (TRT)?
The directory lists 394 clinic profiles tagged for Testosterone Replacement Therapy (TRT). Listing inclusion is not certification, and tags may not reflect current services. Testosterone replacement therapy (TRT) treats clinically diagnosed hypogonadism — low testosterone confirmed by blood tests plus symptoms. Clinical practice guidelines from the Endocrine Society and the American Urological Association (AUA) require two separate morning testosterone measurements before starting treatment, and ongoing monitoring of blood counts and prostate markers while on it.
What TRT is and who it's for
TRT restores testosterone to normal physiologic levels in men with hypogonadism. The Endocrine Society and the American Urological Association (AUA) both require a confirmed biochemical diagnosis — at least two morning blood draws showing low total testosterone (the AUA uses below 300 ng/dL as a reasonable cutoff) — together with symptoms such as low libido, erectile dysfunction, fatigue, or loss of muscle mass.
FDA-approved testosterone products are indicated for men with hypogonadism caused by identified medical conditions. The U.S. Food & Drug Administration (FDA) has cautioned that the benefit and safety of testosterone solely for age-related decline have not been established, which is why reputable clinics test first and treat a diagnosis — not an age.
Delivery methods
- Injections (testosterone cypionate or enanthate, weekly or twice-weekly, IM or subcutaneous) — least expensive, most common in cash-pay clinics
- Topical gels and creams — steady levels, transfer risk to partners and children
- Pellets implanted under the skin every 3–6 months — convenient but hard to adjust once placed
- Oral formulations and nasal gel — newer FDA-approved options, typically more expensive
Risks, side effects, and who should not take it
The most common laboratory side effect is erythrocytosis (elevated red blood cell count), which is why clinical guidelines from the Endocrine Society require monitoring hematocrit. TRT suppresses sperm production — men who want children soon should discuss fertility-preserving alternatives before starting. Other possible effects include acne, fluid retention, breast tenderness, testicular shrinkage, and worsening of untreated sleep apnea.
On cardiovascular safety: the landmark TRAVERSE trial (New England Journal of Medicine, 2023) found testosterone therapy non-inferior to placebo for major adverse cardiac events in middle-aged and older men with hypogonadism and elevated cardiovascular risk, though the treated group had higher rates of atrial fibrillation, pulmonary embolism, and acute kidney injury. AUA guidelines recommend avoiding TRT in men with active prostate or breast cancer, a hematocrit above ~54%, severe untreated sleep apnea, or a recent heart attack or stroke.
How to compare TRT prices
TRT prices and what they include vary by clinic, medication, delivery method, laboratory work, follow-up schedule, and contract terms. This guide does not estimate current prices. Use the directory's price index for eligible clinic-published records with source links, then request a current written breakdown from the clinic before making a decision.
How much does Testosterone Replacement Therapy (TRT) cost?
This guide does not calculate a treatment-specific price median. See the price index for eligible clinic price records and source links; confirm current prices and terms directly with the clinic.
Which clinics offer Testosterone Replacement Therapy (TRT)?
| Clinic | Location | Public Google rating | Transparency |
|---|---|---|---|
| Gameday Men's Health - Layton | Bountiful, UT | — | Not Yet Assessed |
| Gameday Men's Health - San Antonio | San Antonio, TX | — | Not Yet Assessed |
| Ascent TRT & Weight Loss | Burleson, TX | — | Grade D — High Opacity |
| Craft Men's Clinic | Tulsa, OK | — | Grade D — High Opacity |
| TRTMD Health Clinic | Annapolis, MD | — | Not Yet Assessed |
| Advanced TRT Clinic | Cheyenne, WY | 4.9★ (42) | Not Yet Assessed |
| Gameday Men's Health Medford | Medford, MA | — | Not Yet Assessed |
| Atlas Men's Health | East Meadow, NY | — | Grade D — High Opacity |
| Ageless Men's Health | Omaha, NE | — | Not Yet Assessed |
| Gameday Men's Health | Stamford, CT | 4.9★ (135) | Not Yet Assessed |
What clinical guidelines and risks govern Testosterone Replacement Therapy (TRT)?
Important: Testosterone is a Schedule III controlled substance. FDA-approved testosterone products are indicated for diagnosed hypogonadism — not for age-related decline alone. Any clinic that prescribes without confirmed morning labs, or ships medication without a clinical evaluation, is operating outside guideline-based care from the Endocrine Society and AUA. The most common laboratory side effect is erythrocytosis (elevated red blood cell count), which is why clinical guidelines from the Endocrine Society require monitoring hematocrit. TRT suppresses sperm production — men who want children soon should discuss fertility-preserving alternatives before starting. Other possible effects include acne, fluid retention, breast tenderness, testicular shrinkage, and worsening of untreated sleep apnea. On cardiovascular safety: the landmark TRAVERSE trial (New England Journal of Medicine, 2023) found testosterone therapy non-inferior to placebo for major adverse cardiac events in middle-aged and older men with hypogonadism and elevated cardiovascular risk, though the treated group had higher rates of atrial fibrillation, pulmonary embolism, and acute kidney injury. AUA guidelines recommend avoiding TRT in men with active prostate or breast cancer, a hematocrit above ~54%, severe untreated sleep apnea, or a recent heart attack or stroke.
Frequently Asked Questions
What testosterone level qualifies for TRT?
Endocrine Society and AUA guidelines commonly use a total testosterone below roughly 300 ng/dL, confirmed on two separate morning blood draws, plus consistent symptoms. A single low reading is not enough — levels vary day to day and drop when tested later in the day.
How much does TRT cost per month?
Prices vary by clinic, medication, delivery method, and what is included. This guide does not publish a national estimate; compare eligible clinic-published records in the price index and confirm current fees directly with the clinic.
How long until TRT works?
Libido and energy changes are usually noticed within 3–6 weeks. Body-composition changes (muscle, fat) develop over 3–6 months of consistent therapy alongside training and diet.
Is TRT safe for the heart?
The 2023 TRAVERSE trial (New England Journal of Medicine) found no increase in major adverse cardiac events versus placebo in men with diagnosed hypogonadism, but did observe more atrial fibrillation, pulmonary embolism, and kidney injury in the treated group. Men with recent heart attack or stroke are typically not candidates per AUA guidelines. Discuss your cardiac history with the prescribing clinician.
Does TRT cause infertility?
TRT suppresses the hormonal signals that drive sperm production, often dramatically. Men planning to have children should tell the clinic up front — alternatives such as clomiphene or hCG-based protocols can raise testosterone while preserving fertility.
Will I be on TRT for life?
Usually, yes — TRT treats the symptom, not the cause, and natural production is suppressed while on therapy. Stopping typically returns levels (and symptoms) to baseline over several months. Treat it as a long-term commitment with ongoing monitoring.
What lab tests are required before starting Testosterone Replacement Therapy (TRT)?
Required diagnostic labs include Total & Free Testosterone, SHBG, Estradiol, Comprehensive Metabolic Panel (CMP), Lipid Panel, PSA (for men), and Complete Blood Count (CBC) to check hematocrit levels.
What labs should a legitimate TRT clinic order first?
Per Endocrine Society and AUA guidelines: two morning total testosterone levels, LH and FSH (to distinguish testicular from pituitary causes), CBC for hematocrit, PSA for men of screening age, estradiol, and a metabolic panel. A clinic that prescribes without baseline labs is a red flag.
Can I get TRT through telehealth?
Yes — many clinics in this directory operate telehealth models with local lab draws. Testosterone is a Schedule III controlled substance under federal law (21 U.S.C. § 812), so federal and state telehealth prescribing rules apply and change periodically; legitimate telehealth clinics will still require labs and a real clinical evaluation.
References
- Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline (Bhasin et al., 2018) — Journal of Clinical Endocrinology & Metabolism
- Evaluation and Management of Testosterone Deficiency: AUA Guideline — American Urological Association
- Cardiovascular Safety of Testosterone-Replacement Therapy (TRAVERSE trial, Lincoff et al., 2023) — New England Journal of Medicine
- Testosterone Information: Safety Communications and Labeling Requirements — U.S. Food & Drug Administration
Public rating and review totals are attributed to Google Business Profiles and are not reviews collected by this directory.